GENETICS
In 1984, Martinez-Castro et al. (Cytogenetics and Cell Genetics 38:310-312) published a pedigree of a family in which two first cousins had married. They had six children three who were homozygous for t(13q;14q), two who were heterozygous for t(13q;14q), and one with a normal karyotype.1. Should there be a lost fertility in the three homozygous t(13q;14q) offspring?
A. Yes
B. No
2. Calculate the probability of this particular outcome for this family (three translocation homozygotes, two translocation heterozygotes, and one normal karyotype).
Hint: –Binomial distribution, but Note that there are 3categories rather than 2. P = (n!/(x!y!z!))pxqyrz
A.0 C. 0.029 E. 0.660 G. 0.080
B. 0.125 D. 0.500 F. 0.059 H. 1
Please answer Both 1 and 2, they are both parts of the same Homework Question