How does a GnRH agonist (Lupron) decrease fibroid size? What are possible adverse effects? Typical duration of therapy?
a) Increases blood flow; Hypertension; 6 months
b) Decreases estrogen; Hot flashes and bone loss; 3-6 months
c) Stimulates fibroid apoptosis; Nausea and vomiting; 9-12 months
d) Enhances fibroid cell division; Weight gain and insomnia; > 1 year