A female patient has been prescribed doxycycline for acne. She takes ethinyl estradiol/norgestrel, an oral contraceptive, and hydrocodone. Which outcome does the nurse anticipate may occur as a result of an interaction with doxycycline?
1) Hydrocodone: Increased central nervous system (CNS) depression
2) Hydrocodone: Decreased CNS depression
3) Ethinyl estradiol/norgestrel: Increased efficacy
4) Ethinyl estradiol/norgestrel: Decreased efficacy