In a particular human cell, whether heterochromatin or euchromatin is more abundant depends on how active that cell is. But considering that most of the 25,000 or so genes in the human genome are transcriptionally inactive in any given cell, how is it possible for cellular activity to affect the chromatin structure to a degree that significantly alters how a nucleus looks on microscopic images? Since most of the genome is inactive, shouldn't it be in a heterochromatic form, and thus most of the chromatin in any given cell will be heterochromatin?