How are intracellular cues and particularly the par-polarity complex involved in axon formation in hippocampal neurons? What is the evidence?
a. Intracellular cues, particularly the parpolarity complex, are involved in axon formation in hippocampal neurons by regulating the asymmetric distribution of cellular components necessary for axon specification and growth.
b. The parpolarity complex is evidence of its involvement in axon formation in hippocampal neurons through studies showing its localization to the developing axon and its role in establishing axondendrite polarity.
c. Intracellular cues, including the parpolarity complex, are involved in axon formation in hippocampal neurons as demonstrated by experiments in which disruption of the parpolarity complex leads to a loss of axon specification and impaired neuron polarization.
d. The parpolarity complex is implicated in axon formation in hippocampal neurons based on data showing its interaction with other proteins known to be crucial for axon development, such as the microtubule cytoskeletonregulating protein Tau.