Suppose both a group of people with a heritable disease and a control group without the disease are tested for their genotype at the disease locus and their genotype for a large number of different SNPs (single-nucleotide polymorphisms). The disease locus is later determined to be in linkage disequilibrium with one SNP in particular. Select the answers below that describe the two loci in linkage disequilibrium.

At what frequency are the disease allele and a particular nucleotide variant of the SNP found together, compared to the frequency expected by chance?

A. Higher
B. Consistent
C. Lower