Which of the following would be true concerning the endocrine system?

SELECT ALL THAT APPLY

1. The endocrine system influences adjustments that require duration rather than speed, whereas the rapid co-ordinations of the body are controlled by the nervous system.

2. Once a steroid hormone binds with its intracellular receptor, the hormone-receptor complex binds with a specific element on DNA, thereby activating a particular gene.

3. Water soluble hormones exert heir effects primarily by activating second-messenger systems within their target cells.

4. Negative-feedback control tends to maintain hormone levels at a relatively constant set point.

5. Neuro-endocrine reflex control of hormone secretion usually produce a sudden increase in hormone secretion in response to a specific stimulus.