Coya Cusirimay was the daughter of the Inca Topa Inca Yupanqui and Mama Ocllo Coya, and the full sister of Huayna Capac. After his succession to the throne in 1493, she married her brother in accordance with custom. She thereby became the 11th coya of the Inca Empire.
The decline of the Inca Empire started before the Spanish arrived in Inca territory but their arrival accelerated its decline and eventually its fall destroying its civilization