Answer: Sodium and potassium
Explanation: The process by which the sodium and potassium ions moves across the membrane to generate the membrane potential which helps in the signal transduction.
This process is important for a variety of reasons, the movement of ions across membranes generates membrane potential which helps in the transmitting the signals for the relaxation of the muscles which includes heart muscle and muscles of various parts pf the body.
It maintains a balance in the body and if there is any problem in the muscles or cardiac contractions sodium potassium pump is responsible for it.