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In the protonated form of lysine, the positive charge is localized on one nitrogen atom. In the protonated form of arginine, the charge is delocalized on 3 nitrogen atoms. Why does this explain why the side chain of arginine has higher pKa than the side chain of lysine?

Respuesta :

Answer:

[tex]pK_a[/tex] of arginine is higher than that of lysine.

Explanation:

1. According to the Bronsted-Lowry acid-base theory, a stronger base will have a weak conjugate acid.

The positive charge is more stable on [tex]sp^3[/tex] hybrid atom as compared to [tex]sp^2[/tex] hybrid atom.

Therefore, arginine is more basic as compared to lysine.

2. Moreover, 3 nitrogen atoms are present in arginine that has the capability to accept acidic protons as compared to the one nitrogen that is present in lysine.

Higher the [tex]pK_a[/tex], higher will be the basicity.

Therefore, [tex]pK_a[/tex] of arginine is higher than that of lysine.

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