Respuesta :
Answer:
Oncogenes result from a mutation in proto-oncogenes.
Explanation:
- Protooncogenes control the growth and division of cells.
- The proteins encoded by proto-oncogenes include growth factors, growth factor receptors, transcription factors and signal transducers.
- They contribute to the transformation process by driving cell proliferation or reducing sensitivity to cell death.
- Several types of genetic and epigenetic changes convert these proto-oncogenes to oncogenes.
- Oncogenes arise due to the changes that increases the expression of proto-oncogenes .
- Oncogenes are one of the causes of cancers.
A proto-oncogenes can turn into oncogene by following ways:
- A point mutation such as deletion, insertion and substitution in the proto-oncogene can lead to formation of oncogenes.
- Chromosomal translocation may result in activation of proto-oncogene as seen in Burkitt's lymphoma.
- Insertion of a mobile genetic material such as retrovirus changes the gene expression, but leaves their coding sequence intact.
- Activation of proto-oncogene can also occur from reduplication and amplification of DNA sequence.
