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How do genetic/genomic issues influence individual variation in the response to a specific drug? a. Polymorphisms of genes encoding metabolizing enzymes b. Age-related loss of alleles within the cells lining the intestinal tract c. Genetic-based behavior problems that promote poor adherence to prescribed drug regimens d. Single-gene disorders that reduce the function of the kidneys or the liver

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Answer:

The correct answer is option a. "Polymorphisms of genes encoding metabolizing enzymes".

Explanation:

Although doctors prescribe defined doses of drugs according to the patient, an individual can respond differently to a drug according to its specific genomic sequence. The influence of the genome in this case comes from polymorphisms of genes encoding metabolizing enzymes. The study of these polymorphisms is known as Pharmacogenomics, and the most important enzymes that metabolize drugs include: cytochrome P450, cytochrome b5 and NADPH-cytochrome P450.

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