What was a major threat to the empire of Charles V?
a. Protestant rebellion in Spain
b. The War of the Spanish Succession
c. An English invasion of Europe
d. Ottomans advancing across Europe
The correct answer for this question is "d. Ottomans advancing across Europe." The major threat to the empire of Charles V is that when the Ottomans advancing across Europe. It has to be taken into account immediately before it worsens anything.