Answer:
Substitution mutation is a type of mutation which is responsible for sickle cell anemia disease.
Explanation:
Substitution mutation is also called point mutation. In sickle cell anemia, glutamic acid is converted into a valine acid which is the main cause of sickle cell anemia formation. In this mutation, the shape of oxygen carrying cell i. e. hemoglobin changes into a sickle type. This sickle shape of the cell prevents the flow of blood in the capillaries.
