Osteoid-producing osteoblasts must rely upon this organelle to produce primary structures leading to the formation of collagen and calcium-binding proteins.

A ribosome is a complex macromolecular structure in the cell (a cellular organelle) that is involved in protein synthesis . Osteoblasts are cells that produce the osteoid substance (fibers and fundamental substance). Osteoblasts synthesize the organic component of the bone matrix (type I collagen, proteoglycans, proteins involved in cell adhesion, osteocalcin and growth factors) and control the deposition of mineral salts. They have a powerful ribosomal apparatus, consistent with the intense synthesis of proteins they develop. Of these, the most important quantitatively is collagen, but they also synthesize other proteins, among which it should be noted, osteocalcin. In addition to synthesizing proteins, the osteoblast directs bone mineralization. The non-mineralized bone tissue is called «osteoid», and is formed by layers that are synthesized from depth to surface, being defined by the different orientation of the collagen fibers in each of them.