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identified a family in which club foot was inherited as an autosomal dominant trait with reduced penetrance. They discovered a mutation in the PITXI gene that caused club foot in this family. Through DNA testing, they determined that 11 people in the family carried the PITXI mutation, but only 8 of these people had club foot. What is the penetrance of PITXI mutation in this family?

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luisvaschetto

Answer:

Incomplete

Explanation:

A dominant condition has incomplete penetrance when the phenotype associated to this trait is observed in some individuals while other family members carrying the same condition do not show any sign of this trait

An example of incomplete dominance are the mutations in the BRCA1 and BRCA2 genes that have been associated with breast cancer

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