When a nonsense mutation appears at the end of the gene then that part of the gene get cleaved off giving rise to a new protein due to this nonsense mutation seems less damaging.
What is a nonsense mutation?
The substitution of the single base pair, which results in the appearance of a stop codon where previously there was a codon specifying an amino acid is known as a nonsense mutation. The existence of this undeveloped stop codon leads to the production of a shortened, and usually the nonfunctional protein.
The nonsense mutation would seem less damaging if it take place at the terminal of the gene rather than at the beginning as the cleaving of the gene would occur which would give rise to a completely new protein.
Thus, when the nonsense mutation appears at the end of the gene it would be less damaging.
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