In biology, a mutation is an alteration in the nucleotide sequence of the genome of an organism, virus, or extrachromosomal DNA. Viral genomes can be of either DNA or RNA.
Examples: Sickle-cell anemia, because of substitution mutation which is a type of point mutation.
Cystic fibrosis, because of deletion mutation which is also a type of point mutation.
Opitz-Kaveggia syndrome, because of inversion mutation which is a type of chromosomal mutation.