Answer:
B)5-fold
Explanation:
Affinity is the measure of the strength of a single bond between an antibody and an antigen. Avidity is the measure of the strength of the overall connection between antibody and antigen. Avidity depends on affinity and also on the number of antigen binding sites present on the antibody.
Here, it is assumed that both IgG and IgM antibodies have same affinity. Hence, avidity will depend on the number of binding sites. IgG is bivalent which means it has two binding sites. IgM is theoretically decavalent which means it has ten binding sites. So avidity of IgM will be 5 times more ( 2 * 5= 10 ) than IgG isotype.
The avidity of 1g M compared to 1g G assuming both isotopes have same affinity is ; ( B ) 5-fold.
The Avidity is the overall measure of strength of the connections between antibody and antigen and it is dependent on the affinity of the bond ( single ) between an antibody and antigen and the antigen binding sites.
Given that 1gM and 1gG both have the same affinity therefore to determine the ratio in the avidity of both isotypes is dependent on the number of antigen binding sites present in each isotype.
1gG = Bivalent ( 2 sites )
1gM = decavalent ( 10 sites )
∴ The avidity of 1gM compared to 1gG = 10 sites / 2 sites = 5 -folds .
Hence we can conclude that The avidity of 1g M compared to 1g G assuming both isotopes have same affinity is ; ( B ) 5-fold .
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