How would it be possible to have the normal amount of a hormone circulating in the blood and yet have symptoms that indicate a shortage of that hormone?

must be at least 50 words

It is possible to have normal levels of a hormone and also exhibit symptoms that indicate a shortage of that hormone due to HORMONE RESISTANCE.

Hormone resistance is a condition/defect caused by the failure of the target tissues to respond to a specific hormone.

For example, the syndrome of thyroid hormone resistance, also called Refetoff's syndrome, is a genetically inherited disorder caused by a reduced responsiveness of the target tissues to thyroid hormone.

In general, hormone resistance is caused by mutations of hormone receptors (both cell membrane and cytoplasmic hormone receptors) that bind to a specific hormone.

In conclusion, it is possible to have normal levels of a hormone and also exhibit symptoms that indicate a shortage of that hormone due to HORMONE RESISTANCE.

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How would it be possible to have the normal amount of a hormone circulating in the blood and yet have symptoms that indicate a shortage of that hormone? must be at least 50 words

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How would it be possible to have the normal amount of a hormone circulating in the blood and yet have symptoms that indicate a shortage of that hormone?

must be at least 50 words