A negative slope means the line would be going downward, so you would go down first (instead of up as with a positive slope), then over right.
Therefore, you would go down 4 (or negative 4 considering you are going down) and right 1.
Rise over run still applies here. Rise over run is a fancy way of saying to put the number (or slope) in fraction form.
-4 as a fraction would be -4/1.
So start at (5,3), go down 4 and over 1, repeatedly and you got it.
**Just remember the rise over run can be confusing with negative slopes.**
