I believe the answer is: Saharan desert
In Hot Desert such as sahara, there is very few water source that organism can use to drink and replenish the fluid in their body, which is why not many animal can afford to cross the Saharan desert.
Camels is the only animal available that could store a Huge amount of water in their hump, which enable them to cross the desert for a very long time without needing to drink.
