Respuesta :
The cell structure which is largely responsible for controlling the entry and exit of substances into or out of the cell is the plasma membrane.
Answer:
plasma membrane
Explanation:
The plasma membrane is also known as the cell membrane. It is the boundary between the internal components of a cell and its external surroundings. It controls the entry and exit of substances into or out of the cell and thus, facilitates the exchange of substances between the cells and their external environment.