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Jesse Chisholm (circa 1805 - March 4, 1868) (Cherokee) was a Cherokee fur trader and merchant in the American West. He is known for having scouted and developed what became known as the Chisholm Trail, later used to drive cattle from Texas to railheads in Kansas in the post-Civil War period

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Jesse Chisholm was a Cherokee fur trader and merchant in west America. He scouted and developed the Chisholm trail, which became a very popular cattle trail.