Why there are only 20 amino acids, although a amino acid is coded by a single codon with three bases. That means by permutation, 3*3*3=27 amino acids must exist ??? ...?
In nature there are many more variations amino acids than the simple 20 found in humans. However, when analyzing the human genome sequence, there is a code for all 64 permutations (4^3), only some of them share amino acids. This is a safe-guard against mutations of one or two nucleotides. For example, the amino acid Alanine is coded with four different nucleotide sequences: GCA, GCC, GCG, GCU. Also some amino acids code the same like UUU &UUC
