By what means has the overuse of antibiotics in medicine and agriculture lead to the current global problem of antibiotic resistance?

The overuse of antibiotics significantly increases the bacterial mutation rate, causing more antibiotic-resistance mutations to occur.
Humans develop an immunity to antibiotics, rendering them ineffective.
Indiscriminant use of antibiotics selects for resistant bacteria and increases their numbers.
Antibiotic resistance is a fabricated problem used to sell newer and more expensive antibiotics.