In order for the skin to fight off infection more efficiently and of the options listed, the correct choice would be for the skin to secrete more defensins.
Keratinocytes are the cells that constitute the epidermis. They are the most dominant cell type in this region and function to create and maintain this barrier. Though this barrier that they create does in fact aid in avoiding bacterial infection, it does little to fight off an already existing infection.
The correct answer is for the skin cells to secrete a greater number of defensins. These are small cationic proteins which are known as "Host Defense Peptides". What this means is that these defensins will either have direct anti-infection properties, or they will act as signals for the immune system.
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