Respuesta :
Ketones provide an alternative form of energy for the body and ketogenesis is a metabolic pathway that produces ketone bodies. It involves a fatty acid transfer, beta-oxidation of fatty acid, acetoacetyl-CoA formation, 3-hydroxy-3-methylglutaryl-CoA synthesis and acetoacetate formation.
What are ketone bodies?
Ketone bodies are water-soluble and lipoproteins are not needed to cross the membrane. Ketone bodies are lipid molecules with two -R groups attached to a carbonyl group.
The ketogenesis process is carried out in the mitochondria of liver cells. The following are the steps in the ketogenesis process:
- Carnitine palmitoyltransferase takes fatty acids in mitochondria. Fatty acid oxidation by CPT-1 to form acetyl CoA
- Acetoacetyl-CoA synthesis: 2 acetyls CoA combine to form acetoacetyl CoA. The enzyme thiolase catalyzes the reaction.
- 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthesis is catalyzed by HMG-CoA synthase.
- HMG-CoA is broken down into acetoacetate and acetyl-CoA by the action of HMG-CoA lyase.
Thus, these are the statements regarding ketogenesis in the correct order, beginning with a stimulus for ketogenesis.
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