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If your friend is skipping alot of meals and losing alot of weight that is a major health issue and can be fatal. so first you might want to talk to them about what is making them do that. if that doesn't work get them to talk to a doctor or someone
Have a 1 on 1 private conversation. Approach your friend, kindly and firmly ask of everything is ok in their life, if something happened at home, how their mental health is. To make better health choices invite your friend to workout with you. Have them drink more water