As gram-negative bacteria have an extra layer of cell wall therefore it is less sensitive towards antimicrobial chemicals than gram-positive bacteria.
Gram-positive bacterial cell wall is made up of only the peptidoglycan layer and it does not have an extra barrier that protects it from some antimicrobial chemicals.
Gram-negative bacteria have two layers of cell wall peptidoglycan layer and a lipopolysaccharide layer.
Thus, gram-negative bacteria have an extra layer of cell wall.
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