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Suppose a mouse develops loss of sodium pump activity in the thick ascending limb of the loop of henle in all of the nephrons in both kidneys. What problem would you expect this mouse to have?.

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A tendency to drink more water than normal accompanied by excretion of dilute urine.

What happens in the thick ascending limb of loop of Henle?

Sodium chloride (NaCl) is actively reabsorbed by the thick ascending limb of loop of Henle, but water cannot pass through it. A lumen-to-interstitium osmotic gradient and medullary interstitial hypertonicity are consequently produced as a result of this segment's increase in the interstitial fluid's osmolality.

If the sodium pump loses its activity then sodium is not reabsorbed in the thick ascending limb of loop of Henle. The concentration of sodium chloride increases in the interstitial fluid and hence more water will be needed to counter the effect and more dilute urine will be excreted out.

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