An integrated transcriptomic and epigenomic analysis identifies CD44 gene as a potential biomarker for weight loss within an energy-restricted program

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21-07-2022
Mathematics

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An integrated transcriptomic and epigenomic analysis identifies CD44 gene as a potential biomarker for weight loss within an energy-restricted program

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tutorconsortium33 tutorconsortium33 · Answer 1 · 2022-08-02T14:28:03+02:00

An integrated transcriptomic and epigenomic analysis identifies the CD44 gene as a potential biomarker for weight loss within an energy-restricted program: TRUE

What is an integrated transcriptomic and epigenomic analysis?

Because of the interindividual variability in response to weight-loss treatments, new predictive biomarkers are needed to improve the efficacy of weight-loss programs.
The goal of this work is to find new genes that distinguish individual responses to a weight-loss dietary regimen by combining mRNA expression and DNA methylation arrays.
Different expression and DNA methylation profiles were found in LR versus HR.
The integrative analysis of the array data found four genes that were differentially methylated and expressed between groups: CD44, ITPR1, MTSS1, and FBXW5.
In LR, CD44 expression was higher and DNA methylation levels were lower than in HR.

Therefore, the statement "an integrated transcriptomic and epigenomic analysis identifies the CD44 gene as a potential biomarker for weight loss within an energy-restricted program" is TRUE.

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Complete question:

An integrated transcriptomic and epigenomic analysis identifies the CD44 gene as a potential biomarker for weight loss within an energy-restricted program. TRUE or FALSE