Hiremagalur B, Sabban EL. Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration. Molecular brain research. 1995 Aug 1;32(1):109-15.

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22-07-2022
Biology

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Hiremagalur B, Sabban EL. Nicotine elicits changes in expression of adrenal catecholamine biosynthetic enzymes, neuropeptide Y and immediate early genes by injection but not continuous administration. Molecular brain research. 1995 Aug 1;32(1):109-15.

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Tutorconsortium349 Tutorconsortium349 · Answer 1 · 2022-08-05T14:58:46+02:00

Nicotine, a key pharmacologically active component of tobacco smoke, is often regarded as one of the reasons responsible for cigarette smoking's negative repercussions. Nicotine stimulates the sympathoadrenal system, increasing catecholamine synthesis and release into the bloodstream.

In this work, we show that nicotine injections, both single and recurrent, enhance the expression of tyrosine hydroxylase (TH), a rate-limiting enzyme in the catecholamine biosynthesis pathway. In addition, these treatments influenced the expression of dopamine-hydroxylase (DBH) and neuropeptide Y (NPY) in rat adrenals.

Effects of Nicotine:

Nicotine's influence on various transcription factors in the adrenal medulla was investigated. Injection nicotine treatment boosted CREB phosphorylation and activated c-Fos protein without altering members of the jun family. In contrast to the injection results, continuous infusion via osmotic pumps had no effect on any of these parameters.

These findings suggest that nicotine delivery modality influences the activation of many transcription factors and the production of TH, DBH, and NPY.

To learn more about Nicotine from the given link

https://brainly.com/question/1383901

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