The basophilic stippling is a prominent red blood cell, morphologic feature found in lead poisoning (plumbism).
The basophilic stippling is a frequent manifestation of hematologic disease in the peripheral blood, and it is also observable in bone marrow aspirates.
The lead poisoning inhibits the ability to produce hemoglobin by interfering with enzymatic steps in the heme synthesis pathway and reduce red blood cells, which results in the increasing risk of anemia.
The interference of lead in the development of RBCs results as the exposure to a very small amount of lead greatly changes the surface of the red blood cells. The permeability of water gets altered which results in shrinking and so they aren't capable of swelling up like other normal cells.
The hematologic system is involved with lead poisoning where one can find anemia as a result of it.
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