Respuesta :
True, Immature B lymphocytes undergo clonal deletion in the bone marrow.
What are immature B lymphocytes? How does it undergo clonal deletion in the bone marrow?
In the bone marrow and thymus, lymphocytes are born. The names of T cells and B cells come from the organs in which they are born. T cells form in the thymus, whereas B cells form in the bone marrow of adults or the liver of fetuses in mammals.
Most mammals' bone marrow is where immature B lymphocytes are made. The B cell will die via apoptosis, also known as a clonal deletion if it fails at any stage of the maturation process. Positive selection is used in this situation. Negative selection is also used to check the autoreactivity of B cells. These B cells will perish through clonal deletion if they have a high affinity for attaching to self-antigens. In the bone marrow, immature B cells that bind self-antigen perish because they are highly susceptible to antigen binding.
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