A )loss of ADH secretion.
Destruction of the supra-optic nucleus of the hypothalamus can cause loss of ADH secretion. Reason behind this is antidiuretic hormone are synthesized in hypothalamic supra optic nerves .Hence, destruction of supra optic nerve in the hypothalamus will alter the production and secretion of ADH . ADH is stored in posterior pituitary gland and is released into the circulation in response to extracellular fluid changes by the osmoreceptors in the brain.
Deficiency of ADH can cause or insensitivity of the kidney to ADH also known as nephrogenic diabetes insipidus. These patients, if untreated, have the predictable result of dehydration, hyperosmolality, hypovolemia, and eventual death in severe cases.
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