The philadelphia chromosome is a balanced chromosome translocation that forms a new gene called:_____

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22-07-2022
Biology

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The philadelphia chromosome is a balanced chromosome translocation that forms a new gene called:_____

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MubeenaD MubeenaD · Answer 1 · 2022-07-29T00:47:34+02:00

The Philadelphia chromosome results from a balanced translocation that forms a new gene called BCR-ABL. The term clinical remission is synonymous with cure.

The Philadelphia chromosome is a reciprocal translocation involving chromosomes 9 and 22 that is commonly identified in chronic myelogenous leukemia (CML). The break points of the translocation create a fusion of two genes: ABL1 on chromosome 9 and BCR on chromosome 22.

There is technically no cure for chronic myeloid leukemia (CML) caused by the Philadelphia chromosome. Philadelphia chromosome positive chronic myeloid leukemia (Ph+ CML) causes abnormal changes to the chromosomes that lead to high levels of abnormal cells in the bone marrow and blood.

To learn more about chronic myelogenous leukemia here

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