Option e: When the late current was blocked, the reversal potential of the inward current shifted to a negative membrane potential. This observation is not an evidence that helped identify sodium a s the early current of the action potential.
Reversal potential is the potential at which the current reverses direction: it changes from positive to negative.
During a typical action potential, the small resting ion conductance mediated by potassium channels is overwhelmed by the opening of numerous Na+ (sodium ion) channels.
This brings the membrane potential towards the reversal potential of sodium.
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