Respuesta :
The pharmacokinetics of beta-lactam antibiotics favor administration via an extended infusion.
The purpose of this study was to compare clinical outcomes between extended and standard infusions in children.
What are the results of Extended Infusion Cefepime in Pediatric Patients ?
A total of 551 patients (258 extended infusion, 293 standard infusion) met criteria for evaluation. Clinical outcomes among the entire population were similar
- A subanalysis of select populations demonstrated decreased mortality in critical care patients (2.1% vs 19.6%, p = 0.006)
- Outcomes were similar between extended and standard infusions in children.
- Subgroup analyses suggest a possible mortality benefit in the critically ill and decreased readmission rate in bone marrow transplant patients.
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