A Final statement or concluding statement
Tumor cells have experienced a variety of genetic and epigenetic changes as compared to normal cells. Because these alterations frequently underpin cancer genesis, progression, and therapy resistance, the efficacy of model systems is dependent on their capacity to replicate the genetic abnormalities seen in original tumors.
Tumor-derived cell lines have long been utilized to explore the underlying biologic processes in cancer, as well as as screening platforms for identifying and assessing anticancer treatment effectiveness.
Following advancements in high-throughput technology and multigroup collaborative efforts, several -omic measurements across over a thousand cancer cell lines have been produced. These findings supplement large-scale worldwide cancer genomic sequencing initiatives to define patient malignancies, such as The Cancer Genome Atlas (TCGA) and the International Cancer Genome Consortium (ICGC) (ICGC).
Individual data analysis or data integration methodologies will provide an increasing number of hypotheses to examine. Cancer cell lines will continue to be useful in this context and will play an important part in cancer biology research in the future.
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