Respuesta :
It is well accepted that one of the key causes stifling growth is stress.
Previous research has shown that the catecholaminergic and neuropeptide Y (NPY) systems, which are involved in the activation of stress-related neural circuits, regulate growth hormone (GH) release through altering GHRH production.
Catecholaminergic and NPY-immunoreactive (IR) axon varicosities do, in fact, abut the surface of GHRH neurons, creating connections. These juxtapositions appear to be actual synapses and might be the morphological foundation of stress's influence on development.
Aside from catecholamines and NPY, there is a large body of evidence suggesting corticotropin-releasing hormone (CRH), a significant stress hormone, regulates GH secretion.
The architecture of these CRH-GHRH juxtapositions shows that, among other neurotransmitters/neuromodulators, CRH regulates development via direct synaptic processes via influencing hypothalamic GHRH production.
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