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A 1500 iu (300 µg) dose of rhig can suppress immunization to 30ml ml of d-positive whole blood

About 30 mL of D-positive whole blood can prevent immunization with 300 g of RhIg (15 mL of packed rbc). If the gestational age is less than 12 weeks, a dose of 600 IU (120 g) can be adequate. The recommended dosages change from nation to country and even within countries depending on the foetus' development.

In North America, it is accepted that 300 g of RhIg can prevent the immunisation of about 30 mL of whole blood that has tested positive for D. For example, FMH larger than 30 mL of whole blood (for 300 g dosages) and FMH above 12 mL of RBC (for 100 g doses) both call for testing to identify larger foetal bleeds.

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