DNA is single-stranded. There are two types of DNAs, fiber polymer(ssDNA) and double-stranded polymer (dsDNA). Consequently, the polymer binding proteins typically contain fiber DNA-binding proteins (SSBs) and double-stranded DNA-binding proteins(DSBs).
Single-stranded DNA binding proteins (SSBs) and double-stranded DNA binding proteins (DSBs) are two different types of DNA binding proteins that participate in many biological processes.
While SSBs typically serve roles in DNA replication, recombination, and repair, among other processes, DSBs typically operate as transcriptional factors to control the expression of the genes. For the study of protein functions, knowing a DNA binding protein's binding specificity is useful.
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