Which are administration guidelines for transdermal drugs?

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22-08-2022
Medicine

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Which are administration guidelines for transdermal drugs?

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tutorconsortium31 tutorconsortium31 · Answer 1 · 2022-08-25T19:49:15+02:00

To be delivered transdermally, an ideal drug should have the following properties: low molecular weight (less than 1000 Da), affinity for lipophilic and hydrophilic phases, low melting point, have a short half-life and non-irritating.

What is Transdermal drugs ?

TDD is a painless method of systemic drug delivery that involves applying a drug formulation to healthy, undamaged skin. Without building up in the dermal layer, the medication first goes through the stratum corneum and then deeper layers of epidermis and dermis.

The skin is a very effective barrier, so only medications whose molecules are small enough to penetrate the skin can be delivered by this method. This is the main drawback of transdermal delivery systems.

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