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Gene responsible for producing amyloid precursor protein (app) appears to explain the development of History of alzheimer's disease
Their prediction was verified in short order when the amyloid precursor protein (APP) was cloned in 1987. The peptide isolated by Glenner & Wong has come to be known as the Aβ peptide, short for amyloid-β peptide.
What is Amyloid precursor protein ?
The transmembrane protein known as amyloid precursor protein (APP) is crucial for the control of numerous vital cellular processes, particularly in the nervous system where it is involved in synaptogenesis and synaptic plasticity.
- The aberrant breakdown of the amyloid precursor protein (APP) by -secretase and -secretase results in the production of -amyloid peptide, which aggregates into neurotoxic amyloid plaques in the brain tissues and plays a crucial role in the pathogenesis of Alzheimer's disease.
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