In anti-phospholipid syndrome who do not fulfill the criteria for any rheumatic diseases. It limit the cutaneous scleroderma.
Neoplastic disease may cause positive ANA . According to authors -ANA is found in sera from breast , lung , head and neck cancer patients.The finding of ANA positively in health individual is usually unknown significance in most cases is benign. It is listed under immunological disorders in SLE criteria .
Anti-centro-mere antibodies are associated with the CREST syndrome , a limited variant of disease scleroderma , it is also known as systemic sclerosis. It is observed that ANA patterns were the speckled and homogeneous patterns , but in other patterns were rare representing less than 7% .
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