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In the brain, the Anterior cingulate is associated with the perceived unpleasantness of pain sensation.

In human brain, the anterior cingulate cortex (ACC) is the frontal part of the cingulate cortex that resembles the "collar" surrounding the frontal part of the corpus callosum. It  consists of basically Brodmann areas 24, 32, and 33. the Anterior cingulate cortex

The anterior cingulate cortex is basically responsible for the host of the cognitive functions, including the emotional expression, and the attention allocation, and for mood regulation

Short-term meditation increases the blood flow in the anterior cingulate cortex and insula. Asymmetry in the frontal electrical activity has been reported to be associated with the positive mood. One form of the mindfulness meditation, and integrative body-mind training (IBMT) alos improves the positive mood and the neuroplasticity

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