His respiratory center is indicating high carbon dioxide concentration in the blood.
In many cases, a higher CO2 level leads to mild symptoms including headache and fatigue. When the mechanisms designed to protect this balance in your body no longer work, more severe symptoms of difficulty breathing, respiratory failure, seizure, and coma can occur.
The hydrogen ions stimulate the central chemoreceptors. As carbon dioxide increases, so does the number of hydrogen ions, which in turn lowers the pH. The central chemoreceptors actually respond to this pH change caused by the blood PCO2.
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