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If the glomerular filtration rate ( GFR ) of a solute is equal to its plasma renal clearance, then substance must be secreted.

  • Renal clearance is a measurement that is used to analyze and study the function of the kidneys. It varies from one substance to another and it tells us the volume of blood plasma that is completely cleared of a given substance over a time period by the kidney.

For instance, the renal clearance of urea is 65 mL/min. This value means that 65 mL of blood plasma is completed cleared of urea every single minute.

The renal plasma flow is how much blood volume actually reaches the glomerulus of the kidney every single minute while the glomerular filtration rate is the volume of blood plasma that is filtered through the glomerulus and into the Bowman's capsule.

For normal kidneys, the renal plasma flow is 625 mL/min while the glomerular filtration rate is 125 mL/min

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