A stimulus may lead to the contraction of a smooth muscle cell without a change in the plasma membrane potential in a manner which is described below:-
Smooth muscle cells react to chemical messengers, that are extracellular in origin, in a number of ways.
Few of these messengers bring about responses in the plasma membrane which gives rise to secondary messengers, which include chemical messengers like inositol triphosphate (ip3), which are responsible for the release of CA2+ from the sarcoplasmic reticulum.
Therefore, the contraction of a smooth muscle cell can be prevented without a change in the plasma membrane potential.
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